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Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly called nonalcoholic fatty liver disease (NAFLD), is a liver condition that affects people with excess weight, obesity or other metabolic conditions, such as type 2 diabetes, high blood pressure or high cholesterol. Metabolic dysfunction-associated steatotic liver disease (MASLD) is when fat builds up in your liver. It once was called nonalcoholic fatty liver disease (NAFLD).
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MASLD may not cause symptoms. Having obesity or Type 2 diabetes increases the risk of developing it. Nonalcoholic fatty liver disease, or NAFLD (also referred to as metabolic dysfunction-associated steatotic liver disease, or MASLD), is a condition in which excess fat builds up in your liver. This buildup of fat is not caused by heavy alcohol use.
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Metabolic dysfunction-associated steatotic liver disease, or MASLD (formerly called NAFLD) tends to develop in people who have increased body fat or have diabetes, high cholesterol, or high triglycerides. Heavy drinking puts you at a greater risk for fatty liver, but you can get it even due to obesity and other reasons. Learn more about the symptoms, causes, and treatment for NAFLD and AFLD. Nonalcoholic fatty liver disease (NAFLD) affects one-fourth of the global population and is the most common cause of chronic liver disease. Nonalcoholic fatty liver disease (NAFLD) is the buildup of fat in the liver that is not caused by drinking too much alcohol.
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People who have it do not have a history of heavy drinking. NAFLD is usually but not always related to being overweight. For many people, NAFLD causes no symptoms or problems. GLP-1 for Fatty Liver Disease (NAFLD/NASH): 2026 Evidence & Treatment Guide How semaglutide and tirzepatide treat NAFLD and NASH by reducing liver fat, inflammation, and fibrosis. Covers clinical trial results, monitoring, and who benefits most from GLP-1 therapy for liver health.