News Medical: Mammal-specific domain of the prion protein may hold clues to neurodegenerative diseases A study from Bochum describes a mammal-specific domain of the prion protein and offers new approaches for research into neurodegenerative diseases. At first, they cause memory deficits and ... Mammal-specific domain of the prion protein may hold clues to neurodegenerative diseases โ€” A novel sporadic prion protein disease, variably protease-sensitive prionopathy (VPSPr), with distinct features has been described as the first new prion disease since sporadic ...

Context Explanation

News Medical: Study finds link between copper exposure and prion protein neurotoxicity Iowa State University researchers have described with single-molecule precision how copper ions cause prion proteins to misfold and seed the misfolding and clumping of nearby prion proteins. The ... Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and ...

Insight Material

Yeast prions are increasingly recognised as pivotal agents in non-Mendelian inheritance, whereby protein conformations rather than nucleic acids dictate heritable traits. In Saccharomyces cerevisiae ... Case Western Reserve University: New Sporadic Prion Protein Disease Identified by Case Western Reserve CLEVELAND - A new sporadic prion protein disease has been discovered. Variably protease-sensitive prionopathy (VPSPr), as it has been named, is the second type of complete sporadic disease to be ...